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Description
ROR1 (165-305, Frizzled Domain) His Tag Protein, Human/CynomolgusProduct Specification Species Cynomolgus Synonyms ROR1, NTRKR1 Accession Q01973 1 Amino Acid Sequence Glu165 Asp305, with C terminal His Expression System HEK293 Molecular Weight 19 21kDa (Reducing) Purity 95% by SDS PAGE & SEC HPLC Conjugation Unconjugated Tag His Tag Physical Appearance Lyophilized Powder Storage Buffer PBS, PH7. 4, 5% trehalose Reconstitution Reconstitute at 0. 1 1 mg ml according to the size in ultrapure water after rapid
Product Specification
| Species | Cynomolgus |
| Synonyms | ROR1, NTRKR1 |
| Accession | Q01973-1 |
| Amino Acid Sequence | Glu165-Asp305, with C-terminal His |
| Expression System | HEK293 |
| Molecular Weight | 19-21kDa (Reducing) |
| Purity | ＞95% by SDS-PAGE & SEC-HPLC |
| Conjugation | Unconjugated |
| Tag | His Tag |
| Physical Appearance | Lyophilized Powder |
| Storage Buffer | PBS, PH7.4, 5% trehalose |
| Reconstitution | Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation. |
| Stability & Storage | · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃. · 3 months, -20 to -80℃ under sterile conditions after reconstitution. · 1 week, 2 to 8℃ under sterile conditions after reconstitution. · Please avoid repeated freeze-thaw cycles. |
| Reference | Xian J, Sinha N, Girgis C, Oh CS, Cring MR, Widhopf GF 2nd, Kipps TJ. Variant Transcript of ROR1 ENST00000545203 Does Not Encode ROR1 Protein. Biomedicines. 2024 Jul 16;12(7):1573. |
Background
Receptor tyrosine kinase-like orphan receptor (ROR), consisting of ROR1 and ROR2, is a conserved family of receptor tyrosine kinase superfamily that plays crucial roles during embryonic development with limited expression in adult normal tissues. Tyrosine-protein kinase transmembrane receptor ROR1 is also known as Neurotrophic tyrosine kinase, receptor-related 1 (NTRKR1), which belongs to the protein kinase superfamily or tyr protein kinase family or ROR subfamily. ROR1 contains 1 FZ (frizzled) domain, 1 Ig-like C2-type (immunoglobulin-like) domain, 1 kringle domain, 1 protein kinase domain. ROR1 is expressed at high levels during early embryonic development. The expression levels drop strongly around day 16 and there are only very low levels in adult tissues. Isoform Short is strongly expressed in fetal and adult CNS and in a variety of human cancers, including those originating from CNS or PNS neuroectoderm. ROR1 could interact with casein kinase 1 epsilon (CK1ε) to activate phosphoinositide 3-kinase-mediated AKT phosphorylation and cAMP-response-element-binding protein (CREB), which was associated with enhanced tumor-cell growth.
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