Shipping Estimate
USA
- USA
- CAN
- USA
- CAN
Ships within 48 hours · Estimated delivery Jul 9 - Jul 14
Promo Codes Available:
For Your Every Summer RSVP, with Code: SUMMER15
Description
SEK1/MKK4 Rabbit Polyclonal AntibodyProduct Specification Host Rabbit Antigen SEK1 MKK4 Synonyms Dual specificity mitogen activated protein kinase kinase 4; MAP kinase kinase 4; MAPKK 4; JNK activating kinase 1; MAPK ERK kinase 4 (MEK 4); SAPK ERK kinase 1 (SEK1); Stress activated protein kinase kinase 1 (SAPK kinase 1; SAPKK 1; SAPKK1); c Jun N terminal kinase kinase 1 (JNKK); JNKK1; MEK4; PRKMK4; SERK1; SKK1; MAP2K4 Immunogen Synthetic Peptide Location Cytoplasm, Nucleus Accession
Product Specification
| Host | Rabbit |
| Antigen | SEK1/MKK4 |
| Synonyms | Dual specificity mitogen-activated protein kinase kinase 4; MAP kinase kinase 4; MAPKK 4; JNK-activating kinase 1; MAPK/ERK kinase 4 (MEK 4); SAPK/ERK kinase 1 (SEK1); Stress-activated protein kinase kinase 1 (SAPK kinase 1; SAPKK-1; SAPKK1); c-Jun N-terminal kinase kinase 1 (JNKK); JNKK1; MEK4; PRKMK4; SERK1; SKK1; MAP2K4 |
| Immunogen | Synthetic Peptide |
| Location | Cytoplasm, Nucleus |
| Accession | P45985 |
| Antibody Type | Polyclonal antibody |
| Isotype | IgG |
| Application | WB, IHC-P |
| Reactivity | Hu, Ms, Rt, Mk |
| Positive Sample | HEK-293, HeLa, K562, Jurkat, NIH/3T3, mouse brain, C6, rat brain, COS-7 |
| Purification | Immunogen Affinity |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000 | Hu, Ms, Rt, Mk |
| IHC-P | 1:200 | Hu |
Background
SEK1/MKK4 (also known as MAP2K4, MEK4, JNKK1) is a 399-amino-acid dual-specificity protein kinase located on chromosome 17p11.2 that functions as the immediate upstream activator of both JNK and p38 MAPKs in response to diverse extracellular stresses such as osmotic shock, UV radiation, and cytokines; after phosphorylation by upstream MAP3Ks like MEKK1/2, SEK1/MKK4 phosphorylates JNK and p38 on their Thr-Pro-Tyr motifs, thereby linking stress signals to transcriptional and apoptotic programs, and its activity and stability are subjected to negative feedback control through JNK-mediated phosphorylation of the E3 ubiquitin ligase Itch, which then ubiquitinates and targets SEK1/MKK4 for proteasomal degradation .
Shipping Notes
- Free Standard Shipping on $100+ Orders to the USA.
- Except Preorder products are shipped in 48 hours.
- Delivery to the USA:
- Standard Shipping : 3-10 business days
- If time is of the essence, please consider selecting expedited delivery for faster service.
Exchange/Return Notes
- We offer a 30-day return/exchange service after receiving.
- Final sale items are not eligible for returns or exchanges.
- To process your return/exchange, please contact us at [email protected]
- Please click here for more details>>> Return & Exchange Policy
4.0 ★★★★★
Based on 1538 reviews
Sort
Product Reviews
★★★★★ 4
Just right
Color: Dark Green Ribbed, Size: Throw(50"x60")
Lovely color and texture
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on March 12, 2026
★★★★★ 5
You will not regret buying this blanket!
Color: Aqua, Size: Queen/King Size - 80" X 90"
I was actually looking for a cotton blanket to add to my bed for fall and winter. Then I came across THIS one. It happens to be the exact shade of (“seaglass” or teal or aqua or whatever you choose to call it) blue green that I am currently redoing my bedroom in. It was a teense more than I’d planned to spend on this project. But I was in a splurgey mood so I went for it.
I can honesty say that I’d happily pay twice as much. It’s much more beautiful and much more insanely soft than it looks in the pictures. While I don’t know how the blanket feels about me, I can assure you that I am madly in love with this gorgeous thing!
I can’t wait for it to cool off in Southern California so I can roll myself up in it. Maybe I’ll crank the A/C down to 50 degrees and pretend there are more than two seasons (summer and late summer) in California. Anyway, this would make a great gift. It would make a great gift for yourself. Self care is important! Spoil yourself! You, at the very least, deserve a cozy cuddly blanket. I’m certain that this luxurious blanket will cure insomnia. Maybe even depression. I’ve owned it for like 2 hours and I have a whole new outlook on life! I feel pampered, spoiled, like queen of the world, maybe even like Cleopatra!
I think that it should be obvious by now that I’m giving this furry looking blanket two thumbs way way up!
Sometimes I order things from Amazon and by the time they arrive Ive already forgotten about them. I was anxiously awaiting my blanket friends arrival and I was prepared to be very meh. Not this time! Nope! Best purchase ever! I know what I’m getting everyone for Christmas!
Buy several for future use. This blanket has made me deliriously happy!
Update: After owning this blanket for, like, a while, I still love it. Shockingly it washes up beautifully! A word of advice. Fabric softener is a big no no. It gets the fur gummy and feeling like unwashed hair after a month. I imagine. I’ve personally never gone with unwashed hair for more than a day or two. It is at its fluffy and soft best when you use one of those new Downey rinses instead. That seems to remove all residue and it comes out feeling even better than brand new. A word of warning. Do not picnic on this blanket. The fur will encase and preserve your crumbs better than Tupperware. You may find a lost treasure that you don’t actually want in there. Best used for sleeping only.
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on October 12, 2024
★★★★★ 5
So soft and pretty Looks great!
Color: Aqua, Size: Throw Size - 50" X 60", Color: Aqua, Size: Throw Size - 50" X 60"
This blanket is wonderful. I'm not sure if it will last or wash well but it's amazing right now. I was looking for something that had a sort of aqua color that would go with my new sheets that are aqua but still blend with my comforter which has more blue tones in it. This worked great as far as the color.
I took some pictures and my dog is in them because as soon as I put it on the bed she jumped up and was like "oh thanks Mom ...I love this" That is how soft and luxurious this feels.
Others said theirs was shedding. I took mine out of the bag and shook and no shedding. I did have trouble getting it out of the plastic and cut a few pieces with the scissors but once I got it started I just pulled to rip the plastic.
I took one pic so you could see the back. I would say it's like a fuzzy microfiber and the color is identical. It's just te right thickness. I love the design. It's warm to lay under but also has a warm look. It was a good value at just under $30. I know some people said it did not wash well but I'll be super careful when I wash it and even though it says hang dry I might tumble on a very low or cool dryer so that it does not mat. If it's a disaster I'll come back to report but prob wont wash it for a few months. Oh and no weird smells out of the bag so that was a plus for me since I have chemical sensitivities.
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on March 19, 2026
★★★★★ 5
Nice quality! Very soft and comfy!
Color: Aqua, Size: Throw Size - 50" X 60", Color: Aqua, Size: Throw Size - 50" X 60"
So soft and the color is perfect for our room. I love it!
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on February 21, 2026
★★★★★ 5
Lovely Fluffy Faux Fur Blanket
Color: White, Size: Throw Size - 50" X 60"
Lovely, very soft & lightweight. It is a bit thin causing me to worry it might not be overly warm or durable, yet is just what I was searching for to do a photo project.
Thanks!
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on March 11, 2026