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Description
Alexa Fluor® 647 Mouse Anti-Human CD276 Antibody (S-2965)Product Specification Host Mouse Antigen CD276 Synonyms CD276 antigen; 4Ig B7 H3; B7 homolog 3 (B7 H3); Costimulatory molecule; B7H3 Location Membrane Accession Q5ZPR3 Clone Number S 2965 Antibody Type Mouse mAb Isotype IgG1,k Application FCM Reactivity Hu Positive Sample Human monocyte derived mature dendritic cells Purification Protein G Concentration 0. 2 mg ml Conjugation Alexa Fluor 647 Physical Appearance Liquid Storage Buffer PBS, 1% BSA, 0. 3%
Product Specification
| Host | Mouse |
| Antigen | CD276 |
| Synonyms | CD276 antigen; 4Ig-B7-H3; B7 homolog 3 (B7-H3); Costimulatory molecule; B7H3 |
| Location | Membrane |
| Accession | Q5ZPR3 |
| Clone Number | S-2965 |
| Antibody Type | Mouse mAb |
| Isotype | IgG1,k |
| Application | FCM |
| Reactivity | Hu |
| Positive Sample | Human monocyte-derived mature dendritic cells |
| Purification | Protein G |
| Concentration | 0.2 mg/ml |
| Conjugation | Alexa Fluor® 647 |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 1% BSA, 0.3% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, 2 to 8 °C as supplied |
Dilution
| application | dilution | species |
| FCM | 5μl per million cells in 100μl volume | Hu |
Background
CD276, also known as B7-H3, is a type I transmembrane glycoprotein belonging to the B7 family of immune co-stimulatory molecules that is broadly overexpressed on the cell surface of many solid tumors while showing only limited distribution in normal tissues; it modulates both adaptive and innate immunity by interacting with putative receptors on T cells and NK cells to either inhibit or enhance anti-tumor responses, serves as a marker for cancer progression and poor prognosis, and is actively pursued as a therapeutic target through monoclonal antibodies, antibody–drug conjugates, CAR-T cells, and bispecific T-cell engagers.
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