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Description
HMGA1 Recombinant Rabbit mAb (S-R332)Product Specification Host Rabbit Antigen HMGA1 Synonyms High mobility group protein HMG I HMG Y, HMG I(Y), High mobility group AT hook protein 1 (High mobility group protein A1), High mobility group protein R, HMGIY Location Nucleus Accession P17096 Clone Number S R332 Antibody Type Recombinant mAb Isotype IgG Application WB, IHC P, ICC, ICFCM, IP Reactivity Hu Purification Protein A Concentration 0. 5 mg ml Conjugation Unconjugated Physical
Product Specification
| Host | Rabbit |
| Antigen | HMGA1 |
| Synonyms | High mobility group protein HMG-I/HMG-Y, HMG-I(Y), High mobility group AT-hook protein 1 (High mobility group protein A1), High mobility group protein R, HMGIY |
| Location | Nucleus |
| Accession | P17096 |
| Clone Number | S-R332 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | WB, IHC-P, ICC, ICFCM, IP |
| Reactivity | Hu |
| Purification | Protein A |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05%BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000 | null |
| IHC-P | 1:500 | null |
| ICC | 1:500 | null |
| ICFCM | 1:500 | null |
| IP | 1:50 | null |
Background
HMGA1 is a non-histone chromatin protein involved in many cellular processes, including regulation of inducible gene transcription, DNA replication, heterochromatin organization, integration of retroviruses into chromosomes, and the metastatic progression of cancer cells. Recently it has been shown that HMGA1 proteins, HMGA1a and HMGA1b, can cross-link DNA fibers in vitro and can induce chromatin clustering in vivo suggesting a structural role of HMGA1 proteins in heterochromatin organization.
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