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Description
ROR1 (308-395, Kringle Domain) His Tag protein, HumanProduct Specification Species Human Synonyms Inactive tyrosine protein kinase transmembrane receptor ROR1, NTRKR1, Receptor Tyrosine Kinase Like Orphan Receptor 1, Neurotrophic Tyrosine Kinase, Receptor Related 1 Accession Q01973 Amino Acid Sequence Asn308 Asp395 with His Tag at the C Terminus Expression System HEK293 Molecular Weight 17 20kDa (Reducing) Purity >95% by SDS PAGE, RP HPLC&SEC HPLC Conjugation Unconjugated Tag His Tag Physical Appearance
Product Specification
| Species | Human |
| Synonyms | Inactive tyrosine-protein kinase transmembrane receptor ROR1, NTRKR1, Receptor Tyrosine Kinase Like Orphan Receptor 1, Neurotrophic Tyrosine Kinase, Receptor-Related 1 |
| Accession | Q01973 |
| Amino Acid Sequence | Asn308-Asp395 with His Tag at the C-Terminus |
| Expression System | HEK293 |
| Molecular Weight | 17-20kDa (Reducing) |
| Purity | >95% by SDS-PAGE, RP-HPLC&SEC-HPLC |
| Conjugation | Unconjugated |
| Tag | His Tag |
| Physical Appearance | Lyophilized Powder |
| Storage Buffer | PBS, pH7.4, 5% trehalose |
| Reconstitution | Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation. |
| Stability & Storage | · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃. · 3 months, -20 to -80℃ under sterile conditions after reconstitution. · 1 week, 2 to 8℃ under sterile conditions after reconstitution. · Please avoid repeated freeze-thaw cycles. |
| Reference | 1. María Josefina Quezada, Pablo Lopez-Bergami. (2023). The signaling pathways activated by ROR1 in cancer. Cell Signal. 104:110588. |
Background
The receptor tyrosine kinase orphan receptor 1 (ROR1) serves as a receptor for WNT5A and related Wnt proteins, which are crucial during embryonic development. They regulate processes such as cell migration, cell polarity, neural patterning, and organogenesis. ROR1 mediates these functions by transducing signals from the Wnt secreted glycoproteins to the intracellular Wnt/PCP and Wnt/Ca++ pathways.
In adult human cells, especially in cancer cells, research has shown that the WNT5A/ROR1 axis can activate a variety of signaling pathways in addition to the aforementioned ones. These include the PI3K/AKT, MAPK, NF-κB, STAT3, and Hippo pathways. Furthermore, ROR1 is often aberrantly expressed in cancer and has been linked to tumor progression and poor patient survival outcomes. Its role in promoting cell proliferation, survival, invasion, epithelial-to-mesenchymal transition (EMT), and metastasis is significant.
As a result, ROR1 has emerged as a potential therapeutic target, and numerous tools aimed at targeting ROR1 are currently under evaluation in clinical trials for cancer patients.
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